Endocrine Abstracts

Background and aims: Mesenchymal stem cells (MSCs) exert an immunosuppressive effect on immune system and can abrogate in vitro the pro-inflammatory Th1 response to islet antigen GAD in type 1 diabetes by impairing the production of IFN-gamma. The mechanism may involve paracrine factors. Microvesicles (MVs) released from MSCs may account for this paracrine mechanism through a horizontal transfer of mRNA and microRNA. In the present study we evaluated whether MSC-derived...